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AFLATOXIN B1
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DeCS
Descriptor
English
:
Aflatoxin B1
Descriptor
Spanish
:
Aflatoxina B1
Descriptor
Portuguese
:
Aflatoxina B1
Tree Number:
D03.383.663.283.119.075
D03.438.150.119.075
D23.946.587.142.075
Definition
English
:
A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the
Aspergillus flavus
group of fungi. It is also mutagenic, teratogenic, and causes
immunosuppression
in
animals
. It is found as a contaminant in peanuts,
cottonseed
meal, corn, and other grains. The mycotoxin requires epoxidation to
aflatoxin B1
2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites
aflatoxin M1
and Q1.
Indexing Annotation
English
:
/antag permitted but consider also
ANTITOXINS
; DF: AFB1
Pharmacological Action:
Poisons
History Note
English
:
92; was AFLATOXIN B1 (NM) 1980-91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
30277
Unique Identifier:
D016604
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS